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艾美捷科技代理LifeSensors品牌。


LifeSensors成立于1996年,位于美国宾夕法尼亚州费城,是一家为药物发现与研究提供方法和可行性技术方法的生物技术公司。公司致力于为泛素和泛素蛋白酶体通路研究领域提供高品质

的抗体、酶、蛋白质等试剂和试剂盒,产品,是泛素研究者的好选择。


其原核和真核蛋白表达系统SUMOpro和SUMOstar已被世界范围内的学术、政府研究机构和制药、生物技术公司广泛应用。通过提供创新的研究工具,LifeSensors已成为泛素和泛素样蛋

白途径的优质供应商。

LifeSensors公司目前主要的产品有400多种,其产品主要覆盖泛素和泛素蛋白酶体通路等科学应用领域,并且产品线在不断的扩大中。公司开创了两大独家技术平台:用于细胞信号和药物

发现的泛素蛋白酶体系统(UPS),以及增强目的蛋白在大肠杆菌、酵母、昆虫和哺乳动物细胞中表达与纯化的SUMO融合表达系统。泛素蛋白酶体系统正在成为继激酶之后,药物发现的下

一个机遇,必将成为未来许多新型药物的创新来源。作为泛素蛋白领域的先驱公司,药物的发现、分析化合物以及去泛素酶和泛素化酶的高通量筛选正是LifeSensors创新技术的真正亮点。

此外,LifeSensors还为泛素的蛋白质组学提供众多定制技术服务,并且已经开发了各种各样的测定细胞中的生理底物或生物标志物的方法。

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成立27年来,PBL Assay Science一直协助工业界、学术界、政府研究人员开发检测方法和解决蛋白定量问题。PBL Assay Science的产品包括高品质、高灵敏度的ELISA试剂盒、干扰素蛋白和抗体等,此外PBL Assay Science还提供超灵敏细胞因子检测服务等。

 

Now entering our 27th year, PBL Assay Science works hand in hand with industry, academic, and government researchers to help solve difficult assay development and protein quantification problems. Known as a trusted source for high quality, high sensitivity ELISAs as well as interferon proteins and antibodies, PBL has expanded our assay services capabilities, including ultrasensitive cytokine detection services, and increased our human cell-expressed cytokine and growth factor offerings.

 

PBL Assay Science的主要产品包括:

(1)Assay Kits(ELISAs;Multiplex Assays;Cell-Based Assays)

(2)Proteins(Interferons,Cytokines and Growth Factors,Interferon Decoy Receptor)

(3)Antibodies(Monoclonal Antibodies (MAbs);Polyclonal Antibodies (PAbs))

(4)Assay Services(Quantitative Immunoassays;Cell-Based Services;Reagent Development)


 Assay Kits产品列表
品名货号规格
iLite Human Type I IFN Responsive Cells511002.5 ml/vial
Human IFN-Alpha Multi-Subtype ELISA Kit (Serum, Plasma, TCM)41110-11 x 96-well plate
Human IFN-Alpha Multi-Subtype ELISA Kit (Serum, Plasma, TCM)41110-25 x 96-well plates
Human IFN-Alpha Multi-Subtype ELISA Kit (TCM)41105-11 x 96-well plate
Human IFN-Alpha Multi-Subtype ELISA Kit (TCM)41105-25 x 96-well plates
Human IFN-Alpha ELISA Kit (TCM)41100-11 x 96-well plate
Human IFN-Alpha ELISA Kit (TCM)41100-25 x 96-well plates
Human IFN-Alpha All Subtype ELISA Kit, High Sensitivity (Serum, Plasma, TCM)41115-11 x 96-well plate
Human IFN-Alpha All Subtype ELISA Kit, High Sensitivity (TCM)41135-11 x 96-well plate
Human IFN-Beta ELISA Kit41410-11 x 96-well plate
Human IFN-Beta ELISA Kit41410-25 x 96-well plates
Human IFN-Beta TCM ELISA, High Sensitivity41435-11 x 96-well plate
Human IFN-Beta ELISA Kit, High Sensitivity (Serum, Plasma, TCM)41415-11 x 96-well plate
Human IFNGR1 ELISA Kit (Serum, Plasma, Cell Lysate, TCM)415801 x 96-well plate
DIY Human IFN-Lambda 1/2/3 (IL-29/28A/28B) ELISA (TCM)61840-1Materials for 15 x 96-wells
DIY Human IFN-Lambda 2/3 (IL-28A/B) ELISA (TCM)61830-1Materials for 15 x 96-wells
Mouse IFN-Alpha All Subtype ELISA Kit, High Sensitivity (Serum, Plasma, TCM)42115-11 x 96-well plate
Mouse IFN-Alpha ELISA Kit (TCM)42120-11 x 96-well plate
Mouse IFN-Alpha ELISA Kit (TCM)42120-25 x 96-well plates
Mouse IFN-Beta ELISA Kit, High Sensitivity (Serum, Plasma, TCM)42410-11 x 96-well plate
Mouse IFN-Beta ELISA Kit, High Sensitivity (Serum, Plasma, TCM)42410-25 x 96-well plates
Mouse IFN-Beta ELISA Kit (TCM, Serum)42400-11 x 96-well plate
Mouse IFN-Beta ELISA Kit (TCM, Serum)42400-25 x 96-well plates
DIY Mouse IFN-Lambda 2/3 (IL-28A/B) ELISA (TCM)62830-1Materials for 15 x 96-wells
Pig IFN-Alpha ELISA Kit (Serum, Plasma, TCM)47100-11 x 96-well plate
Cynomolgus IFN-Beta ELISA Kit (Serum, Plasma, TCM)46415-11 x 96-well plate
Cynomolgus/Rhesus IFN-Alpha ELISA Kit (Serum, Plasma, TCM)46100-11 x 96-well plate
Human IL-22 ELISA, High Sensitivity (Serum, Plasma, TCM)41701-11 x 96-well plate
Total Human IL-15 ELISA Kit, High Sensitivity (Serum, Plasma, TCM)41702-11 x 96-well plate


 Proteins产品列表
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品名货号规格
Human IFN-Lambda 2, Human Cell Expressed11720-1≥ 1 x 10⁵ units
Human IFN-Lambda 3, Human Cell Expressed11730-1≥ 1 x 10⁵ units
Human IFN-Lambda 1, Human Cell Expressed11725-1≥ 1 x 10⁵ units
Human Erythropoietin (EPO), Ultrapure11965-1500 units
Human Interleukin 22 (Human Cell-Expressed)11701-110 μg
Human Interleukin 22 (Human Cell-Expressed)11701-250 μg
Human Interleukin 15 / IL-15Rα Heterodimer (Human Cell-Expressed)11702-110 μg
Human Interleukin 15 / IL-15Rα Heterodimer (Human Cell-Expressed)11702-250 μg
Mouse Interferon Alpha All-Subtype Neutralizing Viral Protein12185-110 μg
Mouse Interferon Alpha All-Subtype Neutralizing Viral Protein12185-2100 μg
UniversalTM Type I IFN (Human IFN-Alpha Hybrid Protein)11200-11 x 10⁵ units
UniversalTM Type I IFN (Human IFN-Alpha Hybrid Protein)11200-21 x 10⁶ units
Human IFN-Beta 1a, mammalian, carrier-free11410-21 x 10⁶ units
Human IFN-Beta (Beta 1a, Mammalian Expressed)11415-11 x 10⁵ units
Human IFN-Alpha Sampler Set11002-11 x 10⁵ units
Human IFN-Alpha 2a (Alpha A) Protein11100-15 x 10⁶ units
Human IFN-Alpha 2a (Alpha A) Protein, Carrier-Free11101-15 μg
Human IFN-Alpha 2a (Alpha A) Protein, Carrier-Free11101-220 μg
Human IFN-Alpha 2b (Alpha 2) Protein11105-11 x 10⁵ units
Human IFN-Alpha 8 (Alpha B2) Protein11115-11 x 10⁵ units
Human IFN-Alpha 10 (Alpha C) Protein11120-11 x 10⁵ units
Human IFN-Alpha 1 (Alpha D) Protein11125-11 x 10⁵ units
Human IFN-Alpha 21 (Alpha F) Protein11130-11 x 10⁵ units
Human IFN-Alpha 5 (Alpha G) Protein11135-11 x 10⁵ units
Human IFN-Alpha 14 (Alpha H2) Protein11145-11 x 10⁵ units
Human IFN-Alpha 17 (Alpha I) Protein11150-11 x 10⁵ units
Human IFN-Alpha 7 (Alpha J1)11160-11 x 10⁵ units
Human IFN-Alpha 6 (Alpha K) Protein11165-11 x 10⁵ units
Human IFN-Alpha D (Alpha 1) Protein11175-11 x 10⁵ units
Human IFN-Alpha 4a (Alpha M1) Protein11177-11 x 10⁵ units
Human IFN-Alpha 4b (Alpha 4) Protein11180-11 x 10⁵ units
Human IFN-Alpha 16 (Alpha WA) Protein11190-11 x 10⁵ units
Human IFN-Omega11395-125 μg
Human IFN-Beta 1b, E.Coli11420-11 x 10⁵ units
Human IL-28A/IFN-Lambda 2, Carrier-Free11821-125 μg
Human IL-29/IFN-Lambda 1, Carrier-Free11826-125 μg
Human IFN-Gamma11500-150 μg
Human IFN-Gamma11500-2100 μg
Cynomolgus IFN-Alpha 2 (Ile 16), Mammalian16105-11 x 10⁵ units
Rhesus/Cynomolgus IFN-Alpha 214110-11 x 10⁵ units
Feline IFN-Alpha15100-11 x 10⁵ units
Porcine IFN-Alpha17105-11 x 10⁵ units
Bovine IFN-Tau 2, Mammalian19616-11 x 10⁵ units
Mouse IFN-Beta, Mammalian12405-11 x 10⁵ units
Mouse IFN-Beta, Mammalian, Carrier-Free12410-11 x 10⁶ units
Mouse IFN-Alpha A12100-11 x 10⁵ units
Mouse IFN-Alpha 112105-11 x 10⁵ units
Mouse IFN-Alpha 4, mammalian12115-11 x 10⁵ units
Mouse IFN-Alpha 1112125-11 x 10⁵ units
Mouse IFN-Alpha 1312130-11 x 10⁵ units
Mouse IFN-Beta, E.Coli12400-11 x 10⁵ units
Mouse IFN-Beta, Carrier-Free12401-11 x 10⁵ units
Mouse IL-28B/IFN-Lambda 312820-125 μg
Mouse IL-28B/IFN-Lambda 3, Carrier-Free12821-125 μg
Rat IFN-Alpha 1, Mammalian13101-110 μg
Rat IFN-Alpha 14, Mammalian13114-110 μg
Rat IFN-Alpha 113100-11 x 10⁵ units
Rat IFN-Beta13400-11 x 10⁵ units
Rat IFN-Gamma13500-110 μg
<<
 Antibodies产品列表
<
品名货号规格
Anti-Human IFN-Alpha, Clone MMHA-2 (MAb)21100-150 μg
Anti-Human IFN-Alpha, Clone MMHA-2 (MAb)21100-2500 μg
Anti-Human IFN-Alpha, Clone MMHA-1 (MAb)21105-150 μg
Anti-Human IFN-Alpha, Clone MMHA-11 (MAb)21112-150 μg
Anti-Human IFN-Alpha, Clone MMHA-13(MAb)21116-150 μg
Anti-Human IFN-Alpha, Clone MMHA-17 (MAb)21118-150 μg
Anti-Human IFN-Alpha, Clone MMHA-6 (MAb)21125-150 μg
Anti-Human IFN-Alpha, Clone MMHA-9 (MAb)21127-150 μg
Anti-Human IFN-Alpha, Clone MMHA-14 (MAb)21129-150 μg
Anti-Human IFN-Alpha, Clone MMHA-8 (MAb)21110-150 μg
Anti-Human IFN-Beta, Clone MMHB-3 (MAb)21400-150 μg
Anti-Human IFN-Beta, Clone MMHB-1 (MAb)21405-150 μg
Anti-Human IFN-Beta, Clone MMHB-2 (MAb)21410-1500 μg
Anti-Human IFN-Beta, Clone MMHB-12 (MAb)21450-150 μg
Anti-Human IFN-Beta, Clone MMHB-13 (MAb)21455-150 μg
Anti-Human IFN-Beta, Clone MMHB-14 (MAb)21460-150 μg
Anti-Human IFN-Beta, Clone MMHB-15 (MAb)21465-150 μg
Anti-Human IFN-Beta, Clone MMHB-16 (MAb)21470-150 μg
Anti-Human IFN-Alpha/Beta Receptor 1 Antibody, Clone MMHAR-321370-150 μg
Anti-Human IFN-Alpha/Beta Receptor Chain 2, Clone MMHAR-2 (MAb)21385-150 μg
Anti-Human IFN-Gamma Receptor Chain 2, Clone MMHGR-2 (MAb)21585-1250 μg
Anti-Human IFN-Lambda Receptor 1, Clone MMHLR-1 (MAb)21885-150 μg
Anti-Human IFN-Lambda Receptor 1, Clone HLR14 (MAb)21886-150 μg
Anti-Human IFN-Gamma, Clone MMHG-1 (MAb)21500-1500 μg
Anti-Human IFN-Gamma, Clone MMHG-2 (MAb)21550-1100 μg
Anti-Human IFN-Gamma Receptor Chain 2, Clone MMHGR-2 (MAb)21585-1250 μg
Anti-Human IL-28A/IFNL2, neutralizing, Clone MMHL-2 (MAb)21720-1200 μg
Anti-Human Interleukin-28B/Interferon Lambda 3, neutralizing, Clone MMHL-3 (MAb)21730-1100 μg
Anti-Human ISG15, Clone 2.1 (MAb)21900-1100 μg
Anti-Mouse IFN-Alpha, Clone RMMA-1 (MAb)22100-1250 μg
FITC Conjugated Anti-Mouse IFN-Alpha, Clone RMMA-1 (MAb)22100-325 μg
Anti-Mouse IFN-Beta, Clone RMMB-1 (MAb)22400-1250 μg
Anti-Mouse IFN-Gamma, Clone RMMG-1 (MAb)22500-1500 μg
Anti-Pig IFN-Alpha, Clone K9 (MAb)27100-1500 μg
Anti-Pig IFN-Alpha, Clone F17 (MAb)27105-1500 μg
FITC Conjugated Anti-Mouse IFN-Alpha, Clone RMMA-1 (MAb)22100-325 μg
Anti-Human IFN-Alpha, Rabbit Serum (PAb)31101-11 x 10⁵ units
Anti-Human IFN-Alpha, Sheep Serum (PAb)31110-11 x 10⁵ units
Anti-Human IFN-Alpha (All Subtypes), Rabbit Serum (PAb)31135-11 x 10⁵ units
Anti-Human IFN-Beta, Sheep Serum (PAb)31401-12 x 10⁴ units
Anti-Human IFN-Beta, Rabbit IgG, protein A purified (PAb)31405-12 x 10⁴ units
Anti-Human IFN-Beta, Rabbit Serum (PAb)31410-12 x 10⁴ units
Anti-Human IFN-Beta, Goat IgG, Affinity Purified (PAb)31420-1100 μg
Anti-Human IFN-Gamma, Rabbit Serum (PAb)31500-12 x 10⁴ units
Human Type I IFN Neutralizing Antibody Mixture39000-10.2 ml
Anti-Mouse IFN-Alpha, Rabbit Serum (PAb)32100-12 x 10⁴ units
Anti-Mouse IFN-Alpha, Chicken IgY, Purified (PAb)32120-1500 μg
Anti-Mouse IFN-Beta, Rabbit Serum (PAb)32400-12 x 10⁴ units
Anti-Mouse IFN-Beta, Rabbit IgG, Protein A purified (PAb)32401-12 x 10⁴ units
Anti-Mouse IFN-Gamma, Rabbit Serum (PAb)32500-12 x 10⁴ units
Anti-Rat IFN-Alpha, Rabbit IgG, Protein A Purified (PAb)33100-1500 μg
Anti-Rat IFN-Beta, Rabbit IgG, Protein A purified (PAb)33400-1500 μg


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全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com


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Encapsula NanoSciences.jpg

艾美捷科技特约代理Encapsula NanoSciences公司产品。


Encapsula NanoSciences是美国一家致力于提供基于脂质纳米微粒技术(脂质体)的研发和生产的高科技生物纳米技术公司,具有多项知识产权。Encapsula NanoSciences公司现拥有Clodrosome ® , Encapsome ®和Fluoroliposome ® 三个注册商标品牌,提供表面活性脂质体配方和生产服务,包括抗体/多肽交联(Immunosome)、氯磷酸盐脂质体(Clodrosome)及其对照脂质体(Encapsome)、阿霉素脂质体(Doxosome)、DNA和 RNA脂质体 (Genesome)、荧光脂质体(Fluoroliposome)、冻干ATP脂质体(ATPsome)、多款用于人造细胞模型的细胞脂质体(Cellsome)、用于抗肿瘤药物封装的脂质体、多款用于皮肤学及化妆品研发领域的脂质体(Cosmesome) 、以及用于姜黄色素(Curcusome)、肌醇(Inosisome)和宠物专用的营养补充剂脂质体 (Taurosome) 。公司产品服务于学术研究及工业生产等多个领域。通常根据客户需求提供实验室规模的预制脂质体产品。

 

Encapsula NanoSciences is a specialty company focused on providing liposome research, development and manufacturing expertise in the production of lipid-based nanoparticles, also known as liposomes, to clients and partners in both the academic and industrial sectors. Encapsula routinely provides custom laboratory-scale liposome preparations of drug encapsulated liposomes such as Clodrosome® (clodronate liposomes), Encapsome® (plain-control liposomes for clodronate liposomes), Doxosome™ (doxorubicin liposomes), Immunosome™ (reactive liposomes for antibody, protein conjugation), Immunodox™ (reactive liposomes for antibody, protein conjugation containing doxorubicin), Immunogene™ (reactive liposomes for antibody, protein conjugation containing genetic material), Immunofluor™ (reactive liposomes for antibody, protein conjugation containing fluorescent molecules for tracking), Genesome™ (liposomal DNA and RNA), Fluoroliposome™ (fluorescent liposomes), Atpsome™ (ATP liposomes), Cellsome™ (plain liposomes as artificial cell models) and Cosmesome™ (liposomes used in dermatology) to clients in universities and industrial research labs. Encapsula NanoSciences also recently introduced two oral liposomal product lines; NanoLife Nutra for pets and NanoLife Tonics for humans.

 

Encapsula NanoSciences的主要产品包括:

Plain Liposomes as Artificial Cell Models or as Control

Small Molecules Encapsulated into Liposomes

Magnetic Liposomes

Fluorescent Liposomes

Spin labeled Liposomes

Encapsulation of Genetic Materials into the Liposomes

Liposomes used for Electro-Injection

Long-Circulating Sterically Protected Liposomes

Surface Modification of Liposomes

pH Sensitive Liposomes (PSL)

Freeze-Dried Liposomal Systems

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艾美捷科技有限公司

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ProSci Incorporated从事抗体等科研试剂的研发、生产和销售。公司现拥有17000多种单、多克隆抗体,产品涵盖了细胞凋亡、信号转导、免疫、肿瘤、细胞生物、神经生物、传染病等领域。公司的抗体大都经免疫亲和层析纯化,具有高纯度、高亲和力、特异性强等特点,所有的ProSci抗体都经过了严格的验证测试和质量控制,已保证高质量的产品。ProSci的抗体广销於世界30多个国家和地区,得到欧美日等生物医学界科研人员和生物制药公司的研发人员的广泛接受。ProSci直销的产品和ProSci的名字已在520多篇科研论文中出现了1500多次,ProSci的经销商和客户都对ProSci产品的质量和服务十分满意。我们的抗体可用于免疫印迹(Western blot) ,免疫组织化学(IHC),免疫细胞化学(ICC),酶联免疫吸附实验(ELISA)和细胞流式分析(FACS)等方面。此外,ProSci还提供标记二抗,重组蛋白,细胞和组织裂解液,细胞涂片,组织切片,多肽等产品与抗体配套使用。ProSci在美国拥有完整的免疫学试剂开发、生产、检测的生产线,包括自己的厂房和实验动物基地,可为您的研究提供信得过的抗体等科研试剂。

 

ProSci Incorporated is a privately-held biotechnology firm located in San Diego, California. A leader in its field, ProSci’s priority is to provide the highest quality monoclonal, polyclonal, and single domain antibody services in the industry. ProSci’s expertise in antibody production, immunochemistry services, and biological research is realized through customizable services, innovative products, competitive pricing, high-quality research tools, and unparalleled technical support.

 

ProSci的主要产品包括:

Primary Antibodies

Secondary Antibodies

Recombinant Proteins

Lysates

Antibody Beads

Control Antibodies

Detection Sets

Immunoblots

Peptides

Reagents

Slides

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美国Plant Cell Technology公司为商业及研究用植物组织培养实验室和植物种植者开发、生产了旗舰产品PPM™ (Plant Preservative Mixture),它是一种广谱抗微生物剂,可以杀死细菌和真菌细胞,防止真菌孢子的萌发,并在较高浓度下能消除内源性污染的外植体。研究表明PPM™活性成分可以渗透过真菌或细菌细胞壁,抑制柠檬酸循环和电子传递链等中心代谢循环中的关键酶的活性,并且可以抑制培养基中的单糖和氨基酸向真菌和细菌细胞的运输。PPM™能有效地抑制植物细胞和植物组织培养中的通过空气、水、人传播的微生物污染及内源性污染,而不会影响体外种子发芽、愈伤组织增殖和愈伤组织的再生。并且,PPM™具有热稳定性,可以和培养基一起灭菌,同时比常用抗生素价更低廉,可以作为植物组织培养基的标准成分。

 

The principal PCT scientist involved in the development of the PPM™ application is Dr. Assaf Guri. Dr. Assaf Guri holds degrees in genetics, applied genetics and plant breeding from the Hebrew University in Jerusalem and Michigan State University in the US. Before joining Plant Cell Technology, Inc., Dr. Guri worked with the Volcani Agricultural Research Center in Israel, Michigan State University in East Lansing, Michigan and DNAP in New Jersey.

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eENZYME为科学界生产和销售高质量的生物试剂盒和生物分析试剂盒。与NIH密切合作以保证产品在生命科学研究的多个领域成功地使用。努力提供新颖价廉且有效的工具,使实验更容易成功。产品在科研、生物技术、制药和政府的研究实验室中得到广泛的应用,包括药物发现、癌症研究、传染病研究、微生物学和分子诊断。

 

eENZYME is a manufacturer and distributor of high quality biological reagents and bio-assay kits to the scientific community. We work closely with the NIH and CDC communities to guarantee the successful performance of our products for life science research in broad areas. We strive to provide innovative and cost effective tools to make your success easier.

 

Our products are used in academic, biotechnology, pharmaceutical and government research laboratories in many diverse applications that include drug discovery, cancer research, infectious disease research, microbiology and molecular diagnostics.

 

eEnzyme公司的主要产品包括:

Frontline Infectious Disease Products

Infectious Disease Antibodies & ELISA Kits

Recombinant Viral & Bacterial Proteins

Virus ORF cDNA Clone

Influenza Virus Research

HIV Research Tools

GPCR/PDE Cell-Based HTS Assays

Cell Assay & Molecule Detection Kits

PCR Tools

Mol. & Cell Biology Reagents

Animal-Free Human Proteins

Antibody & Protein Production

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艾美捷科技有限公司

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邮箱:sales@amyjet.com

网站:www.amyjet.com

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艾乐美生物科技有限公司(AllerMAbs Co., Ltd.)成立于2015年,是台湾一家专注于生产高亲和力、高纯度并具有过敏原特异性的嵌合人类IgE单克隆抗体的生物公司。公司创办人团队在科研过程中发现市面上缺乏多样的IgE单克隆抗体,特別是具有过敏原特异性的人IgE 单抗。如果能制备出这种抗体,将有助于IgE 相关领域的研究工作。因此,AllerMAbs公司团队开始思考与研究利用基因克隆动物来制造人类 IgE 抗体的可行性,经过数年的努力于 2014年开发出人类IgE 抗体基因嵌入小鼠,通过杂交瘤技术 (Hybridoma technology),成功地研制出分泌嵌合人类IgE 单抗的 IgE 杂交瘤与纯化 IgE 抗体。经测试,此种嵌合人类IgE 单抗的物化性质与对免疫细胞的活性,皆与人类IgE 抗体一致,研究成果于2015 年发表在国际学术期刊上。

 

AllerMAbs的产品解决了目前人类IgE抗体不易制备的问题,让嵌合人类IgE抗体可以成为人类IgE抗体的替代品,并提供一个更稳定、更符合血清IgE检测系统的校正品,让临床血清IgE的检测结果更加准确与可靠。

 

其利用动物基因转殖技术,将组成人类IgE抗体分子的ε重链(Heavy chain)和κ轻链(Light chain)的编码基因(Encoding genes),分別嵌入(Knock-in)小鼠胚胎干细胞(Embryonic stem cells, ES cells)的γ1重链和κ轻链基因的位置,接着把胚胎干细胞分別植入孕母鼠体内,并将其带有嵌入基因之成鼠交互配种,最后得到带有人类IgE抗体重链和轻链基因的基因嵌入小鼠(HεκKI mice),且体内能制造完整的嵌合人类IgE抗体分子。

 

技术优势

容易制备IgE杂交瘤与IgE单抗

过敏原特异性

良好的亲和力与专一性

高纯度与高稳定性

可结合至嗜碱性粒细胞上的IgE受体与刺激細胞

可大量生产与高浓度制备

非人类血液来源(相较于血清IgE抗体)

适合用作检测用的校正品

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