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艾美捷科技代理Gene Tools品牌


Gene Tools是一家生产和销售Morpholino Anti-sense oligos(反义寡核苷酸)的公司,其产品专门用于基因调控的科学研究和药物开发。Gene Tools公司由多位资深科学家组成,为全球客户提供免费的技术咨询和Morpholino 序列设计服务。 Morpholino作为基因调控研究的最佳工具,已被广泛用于:阻断靶mRNA 翻译 (下调基因);诱导RNA选择性剪接 (下调或上调基因);阻断 miRNA;阻断病毒 RNA;阻断 non-coding RNA。


▍Morpholino介绍

Morpholino属于第三代反义寡核苷酸,主要通过阻断蛋白质翻译过程而达到抑制目标基因功能的作用,目前已经广泛用于发育生物学和细胞学实验中,并取得了非常好的实验效果。

Morpholino以吗啉环类似物为基本骨架,这种独特的结构特性使得Morpholino 具有以下几个特点:

● 与其他类型的反义寡核苷酸相比,Morpholino 能更好地抵抗核酸酶的作用;

● Morpholino 与靶序列结合后通过空间位阻效应发挥作用, 不激活RNaseH,不引起目标基因mRNA 的降解 ;

● 针对翻译起始位点区设计的Morpholino 用于抑制蛋白质的翻译,针对 pre-mRNA 剪切位点区设计的Morpholino 可影响mRNA 剪切,得到不 同的转录本,可以方便地用于目标基因结构域的突变研究;

● 与靶序列结合能力强,可以渗入mRNA 的二级结构, 并且特异性好。

配合Morpholino 的使用,Gene Tools公司开发了相应的递送系统,可以安全、高效地将Morpholino 输送至胞内,因此,Morpholino 也可以用于遗传学研究和新药靶标的发现以及验证。此外,Morpholino 可以标上荧光基团、亲和标签以及活性反应基团,以供不同的研究需要。

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▍Gene Tools公司产品介绍

● Custom Morpholino:可以根据目标基因序列定制设计并合成Morpholino,用于体外细胞实验或某些直接显微注射的模型(如斑马鱼、非洲爪蟾胚胎)。

● Vivo-Morpholino:适用于活体动物模型(小鼠,大鼠,狗,灵长类等),细胞培养,器官培养等。通过特殊的末端修饰,提高了其穿透细胞膜进入组织细胞的能力,使得在成年动物(主要是小鼠、大鼠)中进行系统性基因功能研究成为可能。

● Prepared Control Oligos:根据特定需求合成细胞穿透肽偶联的 Morpholino。适用于活体动物模型(小鼠,大鼠,狗,灵长类等),细胞培养,器官培养等。


产品名称Short DescriptionOligo sequenceSKU
Standard Control Oligo Negative control oligoCCTCTTACCTCAGTTACAATTTATAPCO-StandardControl-100
Vivo-Morpholino Standard Control OligoNegative Vivo-Morpholino control oligoCCTCTTACCTCAGTTACAATTTATAPCO-VivoStandardControl-100
Random Control Oligo 25-N25-base random sequence mixtureNNNNNNNNNNNNNNNNNNNNNNNNNPCO-RandomControl-25N-100
Zebrafish p53 oligoDanio rerio apoptosis suppression oligoGCGCCATTGCTTTGCAAGAATTGPCO-ZebrafishP53-100
Zebrafish Chordin Positive Control OligoDanio rerio Chordin positive control oligoATCCACAGCAGCCCCTCCATCATCCPCO-ZebrafishChordin-100-F
Clawed Frog Beta Catenin Positive Control OligoXenopus laevis Beta Catenin antisense oligoTTTCAACCGTTTCCAAAGAACCAGGPCO-BetaCatenin-100-F
Green Fluorescent Protein Positive ControlTranslation blocker for GFP targetACAGCTCCTCGCCCTTGCTCACCATPCO-GFPControl-100
Vivo-Morpholino GFP Positive ControlTranslation blocker for GFP target (Vivo-Morpholino)ACAGCTCCTCGCCCTTGCTCACCATPCO-VivoGFPControl-100
Fluoresceinated Vivo-Morpholino Std ControlNegative Vivo-Morpholino control oligo with 5'FluoresceinCCTCTTACCTCAGTTACAATTTATAPCO-FluorVivoStandardControl-100-F


● Endo-Porter:为了解决Morpholino在体外培养细胞中摄取效率低的问题,Gene Tools 开发了 Endo-Porter 这种特殊的转染试剂。它通过温和的内吞体逃逸机制帮助Morpholino进入细胞质。



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Rieke Metals.jpg

Rieke Metal公司位于美国内布拉斯加州Lincoln市,制造有机卤化锌和聚3-烷基噻吩产品。Rieke Metal提供超过5000种有机金属构件模块及超过40000种精细化学品,并且能够提供定制生产服务。

 

From the Rieke Metals headquarters in Lincoln, Nebraska, we manufacture the broadest line of organozinc halides and poly-3-alkylthiophenes of any company in the world. We offer over 5,000 organometallic building blocks and over 40,000 fine chemicals with the ability to custom manufacture many more. The Rieke team has over 135 years of shared experience conducting inert atmosphere reactions. Our expertise in creating reliable organozinc and Grignard reagents, fine chemicals, semiconducting polymers is unmatched. It’s no surprise that Rieke Metals has been honored to serve many of the largest and most innovative pharmaceutical and electronics companies in the world.

 

Rieke Metals公司主要产品:

1000 - Rieke® Highly Reactive Metals

2000 - Rieke® Organozinc Reagents

3000 - Grignard Reagents

4000 - Rieke® Specialty Conducting Polymers

4100 - Substituted Thiophenes

5000 - Functionalized Benzophenones

5500 - Heterocyclic Ketones

6000 - Functionalized Ketones

6250 - Functionalized Benzoylacetonitriles

6500 - Functionalized Trifluoromethyl Ketones

7000 - Functionalized Ketoacids

7500 - Functionalized Ketoesters

8000 - Functionalized Aldehydes and Acetals

8500 - Functionalized Ketoacetals

9000 - 1-Keto-3-Protected Aldehydes

10000 - Functionalized Terminal Alkenes

11000 - Biphenyls (Heterocyclic, Bipyridines, and Pyridyl Phenylamines)

14000 - Alpha-Ketoesters and Acids

18000 - Cyclopentane Dicarboxylic Acids, Anydrides, Ester Acids, and Derivatives

18500 - Cyclohexane Dicarboxylic Acids, Anydrides, Ester Acids, and Derivatives

Novel Chemical Synthesis fine organic compounds

Novel Chemical Synthesis Grignard reagents

Novel Chemical Synthesis organozinc reagents

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艾美捷科技代理Innovative Biochips品牌全系列产品


Innovative Biochips是休斯顿德克萨斯医学中心(TMC)的衍生公司,专注于开发先进的微流控技术,以尖端的灵敏度和高通量解决传统生物技术面临的难题。科研团队和工程师在为各类生物和生物医学应用开发新型微流体技术方面积累了的经验。通过不断创新和优化技术,Innovative Biochips为生命科学研究提供了更精准的工具,推动生物医学领域的进步。主要产品包括单细胞克隆分析、单细胞成像和配对、球状细胞培养等。


▍Innovative Biochips公司产品线

● 单细胞PCR与测序技术:本系列产品融合标准设备制式与创新微流控设计,提供多种简易、快速、经济的单细胞分离方案:实现单细胞向超微量液体环境的高效转移;完美适配单细胞裂解、PCR及测序等遗传分析流程。

● 单细胞克隆:在重组蛋白生产、基因功能研究与药物筛选中应用广泛。1CellPlate®-96孔超微量微流控板采用标准96孔板规格,结合独特的"孔中孔"微流控设计,为癌细胞、杂交瘤细胞、CHO细胞、CRISPR编辑细胞及干细胞等稳定细胞株开发,提供前所未有的简易单细胞分离方案。

● 单细胞检测:1CellPlate®-Assay 超低体积 96 孔微流控微孔板结合了超小孔和微流控网络,满足了单细胞细胞因子检测的需求。单细胞分泌的细胞因子可被收集并通过质谱进行深度分析。此外,具有显著高细胞因子分泌量的单细胞,也能通过常规移液器轻松回收,用于包括克隆或 PCR 测序在内的下游分析。

● 自动化寿命检测:自动解剖芯片 (AD-Chip) 结合延时显微技术,可在 3 天内对 20 种不同菌株的逾万个单酵母细胞进行自动化全寿命追踪。该芯片能够在整个衰老过程中对单细胞进行高分辨率荧光成像。


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▍Innovative Biochips产品列表


品名货号目录规格
1CellDish-60mmH2-SCD-5PKSingle-Cell Cloning and Analysis, Single-Cell Devices, Single-Cell PCR & Sequencing5 Petri Dishes
1CellDish-Glass BottomH6-SGB-5PKGlass Bottom Devices, Single-Cell Cloning and Analysis, Single-Cell Devices, Single-Cell PCR & Sequencing5 Petri Dishes
1CellPlate-miniP2-SCPM-5PKSingle-Cell Cloning and Analysis, Single-Cell Devices, Single-Cell PCR & Sequencing5 Plates
1CellPlate-Glass BottomP2-SCPM-5PKSingle-Cell Cloning and Analysis, Single-Cell Devices, Single-Cell PCR & Sequencing5 Plates
1CellPlate-96wellP2-SCPM-5PKSingle-Cell Cloning and Analysis, Single-Cell Devices, Single-Cell PCR & Sequencing5 Plates
1CellPlate-96Well Low EvaporationP2-SCPM-5PKSingle-Cell Cloning and Analysis, Single-Cell Devices, Single-Cell PCR & Sequencing5 Plates
1CellAssay-Chamber SlideH7-SCS-5PKGlass Bottom Devices, Single-Cell Cloning and Analysis5 Chamber Slides
1CellAssay Lysis KitK1-SCLS-KITSingle-Cell Cloning and Analysis, Single-Cell Kits, Single-Cell PCR & Sequencing-
1CellArray-Glass BottomH5-GBD-5PKGlass Bottom Devices, Single-Cell Devices, Single-Cell Imaging and Pairing5 Petri Dishes
Cell Pairing PlateP6-CPP-5PKCell Pairing Devices, Single-Cell Imaging and Pairing5 Plates
Gridded Polystyrene Dish for Super Resolution Imaging-70um WellsH11-SPD-10PKSingle-Cell Imaging and Pairing10 Petri Dishes
Gridded Polystyrene Dish for Super Resolution Imaging-50um WellsH12-SPD-10PKSingle-Cell Imaging and Pairing10 Petri Dishes
Gridded Polystyrene Dish for Super Resolution Imaging-30um WellsH13-SPD-10PKSingle-Cell Imaging and Pairing10 Petri Dishes
PicoWell Dish-72K WellsH8-PWD-10PKSingle-Cell Devices, Spheroid Cell Culture10 Petri Dishes
PicoWell Dish-160K WellsH9-PWD-10PKSingle-Cell Devices, Spheroid Cell Culture10 Petri Dishes
PicoWell Dish-300K WellsH10-PWD-10PKSingle-Cell Devices, Spheroid Cell Culture10 Petri Dishes
1CellAssay 3D Culture KitK2-SCTD-KITSingle-Cell Culture, Single-Cell Kits, Spheroid Cell Culture-
Million Microwell DeviceH4-MMD-5PKHigh-Throughput RNA-Sequencing, Single-Cell Devices, Single-Cell PCR & Sequencing5 MMDs
PicoWells In 6-Well PlateH8-PWP-5PKGlass Bottom Devices, High-Throughput RNA-Sequencing5 Plates
PicoWells In Chamber SlideH9-PCS-5PKGlass Bottom Devices, High-Throughput RNA-Sequencing5 Chamber Slides
Hole Array-1536S1-SHA-1536-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Plates
Hole Array-384S2-SHA-384-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Plates
Hole Array-6wellS3-SHA-900-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Plates
Hole Array-60mmS4-SHA-350-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Petri Dishes
Hole Array-Glass BottomS5-SHA-75-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Petri Dishes
Hole Array-SlideS6-SHA-240-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Slides
Hole Array-CoverslipS7-SHA-240-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Coverslips
Hole Array-ChamberS8-SHA-160-12PKHigh-Density Cell Culture and Imaging, Standard Hole Array12 Chamber Slides
Automated Dissection ChipA1-AD-5PK-1Yeast Aging Assays5 Chips
Automated Dissection Screening ChipA3-ADS-5PKYeast Aging Assays5 Chips



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艾美捷科技代理Viagen Biotech品牌。

Molzym公司致力于提供先进的分子生物学工具和解决方案,以支持全球的研究人员、科学家和生物技术公司在生命科学研究、分子诊断和生物制药领域的工作。公司以其对产品质量的严格把控和对客户需求的深刻理解而受到客户的信赖。

Viagen Biotech致力于开发高质量的DNA提取系统和相关试剂,以支持全球的学术研究、生物技术和制药公司的研究工作。DirectPCR® DNA Extraction System(DirectPCR® DNA提取系统)在业界具有很高的口碑。Viagen Biotech公司的核心产品与技术为DirectPCR® DNA Extraction System:这是一种单管系统,用于从小鼠尾巴、耳片、卵黄囊和培养细胞内快速制备DNA。该系统消除了任何溶液转移或开管步骤,从根本上节省了时间和精力。DirectPCR®试剂不仅介导生物样品的快速溶解,还包含有效抑制原油裂解液的抑制活性的PCR抑制剂,同时最大限度地保持完整的基因组DNA的释放。Viagen Biotech公司其他相关产品包括蛋白酶K溶液、E-Prep DNA提取试剂等在内的多种分子生物学试剂;这些试剂广泛应用于分子生物学实验,特别是在DNA提取和纯化过程中。Viagen Biotech的产品适用于需要进行基因分型和遗传分析的实验室。DirectPCR®试剂特别适合于从小鼠等实验动物中提取DNA,用于发育生物学、遗传学研究等领域。

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Nanoprobes.jpg

Nanoprobes公司专业生产免疫金标记和免疫测定试验产品。其独特的金标技术使用化学交联的金属和纳米颗粒团簇作为标记。与胶体金颗粒静电吸附在抗体和蛋白质上的传统免疫金探针不同,本公司的金标是与生物分子在特定位点交联的不带电荷的分子。这使我们的探针具有胶体金不具备的范围和灵活性。我们的标记可以附着在任何带有反应基的分子上– 蛋白质、多肽、寡核苷酸、小分子和脂类 - 以检测和定位这些分子。其他标记可以与我们的金标共同使用,我们独特的荧光纳米金探针在一个探针中结合了纳米金(nanogold®)和荧光素,用于荧光和电镜两种技术共同进行样品成像。

 

Nanoprobes was founded in 1990 by Dr. James F. Hainfeld, along with a group of scientists who were also alumni of Brookhaven National Laboratory. The independent research facility they formed has allowed Dr. Hainfeld and his colleagues the freedom to pursue some of the greatest challenges in research: seeking cures for cancer and other diseases.

 

While part of the funding for these endeavors has come from research grants, another source had to be found, as the scientific community faces ever-increasing government cutbacks. To this end, Nanoprobes began to offer many of the nanoparticle technologies developed by its members for use in other scientists' research.

 

Nanoprobes公司主要产品:

AuroVist™ 15 nm & 1.9 nm X-ray Contrast Agent

Conjugates

Enhancement / Developers

EnzMet™ ultra-sensitive

Gold Nanomaterials: Functionalized Nanoparticles

Gold Nanoparticle Reagents

Histadine (His) Tag Labeling

Recombinant Protein Detection

FerroMag™ Magnetic nanoparticles

Negative Stains for EM

Xray Contrast Agents

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网站:www.amyjet.com


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